- New! Pay with your credit card — fast, secure, and easy checkout.
- NOT FOR HUMAN CONSUMPTION
- RESEARCH USE ONLY
- FOR LABORATORY RESEARCH PURPOSES ONLY
- NOT INTENDED AS A DRUG, FOOD ADDITIVE, OR COSMETIC
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondria-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome. Its discovery established a new category of bioactive peptides translated from mitochondrial DNA rather than nuclear DNA, prompting research into mitochondrial-to-nuclear retrograde signaling.
In vitro studies have examined MOTS-c’s activation of AMPK (AMP-activated protein kinase) and its downstream effects on glucose uptake in skeletal muscle cell lines. Rodent studies have used MOTS-c as a tool compound to study mitochondrial stress responses and exercise-associated metabolic adaptations, with a focus on the folate cycle, methionine metabolism, and AICAR-mediated AMPK activation.
MOTS-c occupies a unique position in mitochondrial biology research because it represents one of the first peptide signals demonstrated to travel from the mitochondria to the nucleus and regulate nuclear gene expression in response to metabolic stress. PeptiFy Labs supplies MOTS-c at 99%+ purity in lyophilized form with independent third-party COA verification.
For laboratory and research use only. Not for human or veterinary use.
Mitochondria-derived peptide (MDP) for AMPK signaling and mitochondrial biology research. Supplied lyophilized at 99%+ purity with Janoshik-verified COA.
Price range: $55.99 through $139.99
⚠️ NOT FOR HUMAN CONSUMPTION — RESEARCH USE ONLY ⚠️
All products sold by PeptiFy Labs are intended strictly for laboratory and scientific research purposes only. They are not intended as drugs, food additives, cosmetics, or household chemicals, and have not been evaluated or approved by the FDA. These substances have not been sterilized or tested for safety or efficacy in humans or animals. By purchasing, you certify that you are at least 21 years of age, a qualified researcher, familiar with the hazards associated with these compounds, and will handle them in accordance with all applicable local, state, and federal laws.
You must be over 21 to preview our website
We require visitors to be 21 years old or over, please verify below.
Are you over 21 years of age?
⚠️ NOT FOR HUMAN CONSUMPTION — RESEARCH USE ONLY ⚠️
All products sold by PeptiFy Labs are intended strictly for laboratory and scientific research purposes only. They are not intended as drugs, food additives, cosmetics, or household chemicals, and have not been evaluated or approved by the FDA. These substances have not been sterilized or tested for safety or efficacy in humans or animals. By purchasing, you certify that you are at least 18 years of age, a qualified researcher, familiar with the hazards associated with these compounds, and will handle them in accordance with all applicable local, state, and federal laws.
